Unveiling New Insights: A Comprehensive Questionnaire-based Single-Center Study of Sebaceous Nevus

Jiamin Jin¹Tao Dai²Lu An³Bohan Lai¹Jieyu Gu¹Boxuan Wei¹Shen Wang^1*Feng Xie^1*

• ¹Department of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
• ²Department of Wound Reconstructive Surgery, Tongji Hospital of Tongji University, Shanghai, China
• ³Department of Burn and Plastic Surgery, Huai’an 82 Hospital, Huaian, Jiangsu, China

Sebaceous nevus (SN) is a rare, benign, congenital tumor. However, limited information exists on its clinical features, familial influences, quality of life (QoL) impact, and treatment outcomes in Chinese patients. This study aimed to comprehensively examine these aspects by conducting a questionnaire-based survey among patients with SN who visited the Department of Plastic Surgery at Shanghai Ninth People's Hospital between January 2018 and December 2023. Healthy control children were recruited using the 'best friends' principle to assess familial influences. QoL impact was measured using the Children's Dermatology Life Quality Index (CDLQI). Our analysis revealed that the severity of skin-related symptoms correlated with the extent of hyperplasia and lesion size. Additionally, maternal factors during pregnancy—including medication use, secondhand smoke exposure, toxic chemical contact, and illness (notably COVID-19 infection)—were significantly associated with a higher incidence of SN. Most patients reported mild to moderate QoL impact. Surgical treatment demonstrated higher satisfaction rates compared to laser therapy, highlighting its effectiveness, particularly for easily removable lesions. These findings suggest that hyperplasia and lesion size may predict symptom severity, and the observed association between maternal COVID-19 infection and the occurrence of SN warrants further investigation.