ORIGINAL RESEARCH article
Front. Oncol.
Sec. Cancer Molecular Targets and Therapeutics
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1529980
Risk factors for adverse reactions caused by abemaciclib in breast cancer therapy
Provisionally accepted
- 1Department of Pharmacy, The Affiliated Hospital of Qingdao University, Qingdao, China
- 2Shaoxing Second Hospital, Shaoxing, Zhejiang Province, China
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In recent years, a range of cyclin-dependent kinase 4/6 (CDK4/6) inhibitors have been identified as significantly improving the survival of patients with hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-) breast cancer. As the use of CDK4/6 inhibitors continues to increase, safety concerns have garnered increasing attention. This study retrospectively collected, processed, analyzed, and evaluated the safety profile of abemaciclib, a CDK4/6 inhibitor with broad indications and a high clinical utilization rate. Additionally, potential influencing factors associated with common adverse reactions were explored to provide a foundation for its rational clinical application.
Keywords: Abemaciclib, breast cancer, Diarrhea, Neutropenia, CDK4/6 kinase
Received: 18 Nov 2024; Accepted: 02 Jun 2025.
Copyright: © 2025 Guo, Quan, Sun, Han, Zhang, Cang and Xing. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Qie Guo, Department of Pharmacy, The Affiliated Hospital of Qingdao University, Qingdao, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.