ORIGINAL RESEARCH article
Front. Oncol.
Sec. Gynecological Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1532772
This article is part of the Research TopicCuproptosis and Tumors, Volume II: From Basic Research to Clinical TranslationView all 4 articles
Construction of a novel cuproptosis-related gene signature for predicting microenvironment, prognosis and therapeutic response in cervical cancer
Provisionally accepted
- 1Shandong University, Jinan, China
- 2Qilu Hospital, Shandong University, Jinan, Shandong Province, China
- 3People’s Hospital of Rizhao, Rizhao, China
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Cervical cancer is a common malignant tumor in females, and its carcinogenesis needs further elucidation. Cuproptosis is a novel mode of cell death and its role in cervical cancer is largely unknown. We constructed a six-gene signature based on cuproptosis-related genes (CRGs) using consensus clustering analysis which further classified the patients into Cluster A and Cluster B. Kaplan-Meier survival analysis revealed that the prognosis of patients with cervical cancer in Cluster B was significantly better than in Cluster A (p=0.027). By analyzing the differentially expressed genes (DEGs), we optimized the subclassification as high and low DEG score types, and revealed their differences in prognosis, copy number variation and single nucleotide variation. The scoring model showed effectiveness in distinguishing prognosis, tumor staging, immune microenvironment, immunotherapy and chemotherapy sensitivity. Moreover, the overexpression of FOXJ1 (one of the DEGs) significantly decreased the proliferation, invasion, migration and Epithelial-Mesenchymal Transition (EMT) process in cervical cancer cells. FOXJ1 promoted cuproptosis in cervical cancer cells, thereby inhibiting their proliferation, migration, and invasion capabilities. Our study sheds light on the role of cuproptosis in carcinogenesis and is expected to facilitate the development of personalized treatment for cervical cancer.
Keywords: cuproptosis, Tumor Microenvironment, prognosis, Therapeutic response, cervical cancer
Received: 22 Nov 2024; Accepted: 11 Sep 2025.
Copyright: © 2025 Wang, Cui, Liu, Men, Wang, Hu, Zhang and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xiao Wang, wangxiao08@sdu.edu.cn
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