ORIGINAL RESEARCH article
Front. Oncol.
Sec. Surgical Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1535089
The Impact of Management Traps on Surgical Strategies in Parathyroid Benign and Malignant Tumors-Related PHPT: A Retrospective Cohort Study
Provisionally accepted
- 1First Affiliated Hospital, Dalian Medical University, Dalian, China
- 2The 967th Hospital of Chinese People’s Liberation Army, Dalian, Liaoning Province, China
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Background: Reducing the incidence rate of persistent/recurrent HPT after surgery is the key to the treatment of PHPT. The pitfalls of preoperative, intraoperative, and postoperative management in PHPT patients and their potential impact on surgical strategies need to be comprehensively investigated. Methods: The demographic, biochemical, radiological results and other clinical data of the enrolled 112 patients with primary hyperparathyroidism undergoing surgical treatment were obtained from our database in this retrospective cohort study. One-way analysis of variance was used for normally distributed variables, and Kruskal-Wallis H test was used for non-normally distributed variables. Pearson's chi-square test or Fisher's exact test was used for categorical variables, as appropriate. Results: The patients were divided into parathyroid adenoma group and atypical parathyroid tumor + parathyroid carcinoma group. The serum calcium levels, serum PTH levels in the APT+PC group were higher than those with benign lesions, but there was some overlap; and the clinical data showed no specificity in the differentiation of benign and malignant parathyroid tumors. A more significant finding in this cohort was that the tumor size was significantly larger in persistent/recurrent HPT group than in non-persistent/recurrent group (30.0±12.6 mm vs.19.1± 8.3 mm, p < 0.01).In PHPT, there are pitfalls in preoperative, intraoperative, and postoperative management of parathyroid tumors, which affect the choice of surgical strategies. It is prudent to utilize the tumor-free margin En bloc resection in a variety of parathyroid neoplasms, in order to seek the chance of cure and avoid reoperation as much as possible.
Keywords: primary hyperparathyroidism, Parathyroid adenoma, atypical parathyroid tumor, parathyroid carcinoma, Surgical strategies, Management trap
Received: 02 Feb 2025; Accepted: 21 Apr 2025.
Copyright: © 2025 Zhu, Lv and Jiao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Guang-wen Zhu, First Affiliated Hospital, Dalian Medical University, Dalian, China
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