REVIEW article
Front. Oncol.
Sec. Cancer Genetics
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1543590
The Role of MYEOV Gene: A Review and Future Directions
Provisionally accepted
Yidan Xi
Yanan GeMingzhe Jiang
Dong ZhaoErshu ZhaoFei Cai
Xinlong WangJiatong LiXuefei LiuTingting Li
Zhendong Zheng*- Northern Theater Command General Hospital, Shenyang, China
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The overexpressed gene MYEOV in multiple myeloma, as an oncogene, has been widely recognized for its high expression levels in various malignant tumors. MYEOV plays a significant role in multiple malignancies, particularly in diseases such as multiple myeloma, breast cancer, lung cancer, pancreatic cancer, and esophageal cancer. The presence of the open reading frame of MYEOV in humans and other primates suggests its potential protein-coding capacity, although direct evidence of functional MYEOV protein is currently lacking. The role of MYEOV in various tumors is not limited to its direct effects as an oncogene; it also includes its complex role in tumor cell signaling pathways and its ability to participate in miRNA regulatory networks as a competing endogenous RNA (ceRNA). Studies have shown that MYEOV may affect the expression of cancer-related genes through enhancer activity. This article aims to provide a comprehensive review of the role of MYEOV, its involvement in signaling pathways in tumor cells, and the latest advancements in MYEOV-targeted therapies.
Keywords: ：MYEOV, target, Biomarker Therapy, signaling pathway, tumor
Received: 03 Mar 2025; Accepted: 20 May 2025.
Copyright: © 2025 Xi, Ge, Jiang, Zhao, Zhao, Cai, Wang, Li, Liu, Li and Zheng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Zhendong Zheng, Northern Theater Command General Hospital, Shenyang, China
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