Developing a Predictive Model for Neoadjuvant Therapy in HER2 Overexpression Breast Cancer Using Multi-Parameter MRI Radiomics: twocenter retrospective study

Lingling Wang¹Jingru Yang¹Li Yang²Yun Zhu²Xiaomin Tang²Xinyu Cao¹Wenbo Kang³Haitao Sun^4*Zongyu Xie^2*

• ¹School of Medical Imaging, Bengbu Medical University, Bengbu, China
• ²The First Affiliated Hospital of Bengbu Medical University, Bengbu Anhui, China, Bengbu, China
• ³Bengbu Medical University, Bengbu, China
• ⁴Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Medical Imaging, Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai, China

To explore an MRI-based radiomics model for predicting the efficacy of neoadjuvant therapy (NAT) for breast cancer with HER2 overexpression.: A total of 133 patients with HER2 positive breast cancer who underwent neoadjuvant therapy were retrospectively enrolled and divided into pathological complete response (PCR) and non-PCR groups. The patients from two centers were split into a training group (n=68) and a test group (n=65). MRI sequences (fs-T2WI, DWI, DCE-MRI) were used to outline regions of interest (ROI). Optimal features were selected using f-classif function and LASSO regression, and a multi-parameter MRI radiomics score (Rad-score) was constructed via logistic regression. Clinical independent predictors were identified to build a clinical model, and a nomogram was developed by combining Rad-score with these predictors. Model performance was evaluated using AUC, DeLong test, calibration curves, and decision curve analysis (DCA). Results: In this study, multivariate analysis identified key predictive clinical factors for pCR, including Ki-67 increment index and tumor morphology. Additionally, a total of 3375 radiomics features were extracted, and 7 key features were selected for model construction. Compared with the image group model and clinical model, the nomogram model based on imaging group had the best predictive performance (training group AUC: 0.894, sensitivity 83.72%, specificity 84.00%, test group AUC: 0.878, sensitivity 88.64%, specificity 71.43%). The calibration and decision curve analyses confirmed its strong consistency and clinical utility compared to individual models. Conclusion: The nomogram model based on multi-parameter MRI has a steady performance in predicting the efficacy of NAT in breast cancer patients with HER2 overexpression, which provides important guidance for clinical treatment and decision-making.