REVIEW article
Front. Oncol.
Sec. Gastrointestinal Cancers: Hepato Pancreatic Biliary Cancers
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1544061
Advances in hepatic arterial perfusion chemotherapy for hepatic metastases
Provisionally accepted
- 1Shandong First Medical University, Tai'an, China
- 2Shandong Provincial Qianfoshan Hospital, Jinan, China
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Hepatic arterial infusion chemotherapy (HAIC) is one of the local treatment modalities employed for liver metastases. HAIC targets the delivery of chemotherapy drugs to the affected area by inserting a catheter into the tumor's blood-supplying artery. This approach not only enhances drug concentration within the tumor site, but also significantly reduces systemic side effects. Currently, there are various chemotherapeutic regimens available for HAIC in liver metastases; however, determining the optimal therapeutic agent remains elusive. This article provides a comprehensive review of HAIC dosing regimens and multimodal therapy for liver metastases originating from colorectal, breast, and gastric cancers. Meanwhile, this paper briefly outlines ongoing research on HAIC treatment for liver metastases associated with esophageal cancer, gastroenteropancreatic neuroendocrine tumors, and uveal melanoma.
Keywords: HAIC, Hepatic Metastases, Treatment, Radiotherapy, Locoregional therapy
Received: 12 Dec 2024; Accepted: 19 May 2025.
Copyright: © 2025 Ou, Li, Chang, Li, Chen and Jiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Guijie Li, Shandong Provincial Qianfoshan Hospital, Jinan, China
Feng Chen, Shandong Provincial Qianfoshan Hospital, Jinan, China
Song Jiang, Shandong Provincial Qianfoshan Hospital, Jinan, China
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