ORIGINAL RESEARCH article
Front. Oncol.
Sec. Gynecological Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1547771
This article is part of the Research TopicDeep Learning for Medical Imaging ApplicationsView all 16 articles
6-Gingerol Promotes Apoptosis of Ovarian Cancer Cells Through miR-506/Gli3 Signaling Pathway Activation
Provisionally accepted
- 1Second Affiliated Hospital of Nanchang University, Nanchang, China
- 2Nanchang University, Nanchang, Jiangxi Province, China
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Purpose: Ginger rhizomes have shown potential for promoting human health, including the prevention and treatment of cancer. Here, we investigated the anticancer activities of 6-gingerol and explored its mechanisms of action in ovarian cancer cells. Methods: SKOV3 ovarian cancer cells were treated with different concentrations of 6-gingerol. Clonogenic assays, Flow cytometry, and Western blotting were used to evaluate cell survival and apoptosis. RT-qPCR and transfection experiments were performed to assess the role of miR-506, and bioinformatics tools were used to identify Gli3 as a target gene. Results: In vitro, ovarian cancer cells underwent apoptosis following 6-gingerol treatment. 6-Gingerol suppressed Gli3 expression without affecting Bax, Bcl-2, or Bcl-xL levels. Low miR-506 expression was observed in ovarian cancer tissues, whereas 6-gingerol significantly promoted its expression. miR-506 directly suppressed Gli3 expression and induced apoptosis in SKOV3 cells. Conclusions: Our results indicate that gingerol promoted the upregulation of miR-506, leading to the induction of apoptosis in ovarian cancer cells. This study supports the potential of 6-gingerol-based therapy for ovarian malignancies.
Keywords: ovarian cancer, 6-gingerol, Apoptosis, miR-506, Gli3
Received: 18 Dec 2024; Accepted: 25 Aug 2025.
Copyright: © 2025 Jun, Hong-Hu, Hui, Huan, Xiao-Qing, Xiao-Ju and Xue-Xin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Wu Hong-Hu, Second Affiliated Hospital of Nanchang University, Nanchang, China
He Xiao-Ju, Second Affiliated Hospital of Nanchang University, Nanchang, China
Cheng Xue-Xin, Second Affiliated Hospital of Nanchang University, Nanchang, China
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