ORIGINAL RESEARCH article
Front. Oncol.
Sec. Head and Neck Cancer
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1548742
This article is part of the Research TopicAdvances in the Treatment of Nasopharyngeal CancerView all 7 articles
Random forest model analysis of influencing factors of chemotherapy-induced peripheral neuropathy in patients with nasopharyngeal carcinoma: a cross-sectional survey study
Provisionally accepted
- First Affiliated Hospital, Guangxi Medical University, Nanning, China
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Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a progressive and persistent condition that can significantly affect the quality of life of patients.Even after the cessation of chemotherapy, symptoms of CIPN may endure for an extended period. Despite its considerable impact, there is a paucity of research examining the effects of CIPN on patients.: To investigate the current status of CIPN in patients with nasopharyngeal carcinoma (NPC) and accurately identify factors influencing neurotoxicity based on the Random Forest algorithm.Method: A total of 289 patients with NPC were admitted to the Radiotherapy Department of the First Affiliated Hospital of Guangxi Medical University between August 2023 and April 2024 to investigate the current status of neurotoxicity, cognitive impairment, fatigue, and hand-foot syndrome. To rank the importance of the influencing factors of CIPN in NPC patients, a random
Keywords: random forest model, nasopharyngeal cancer, Chemotherapy-induced peripheral neuropathy, Cross-sectional study, Symptom Management
Received: 20 Dec 2024; Accepted: 30 Jun 2025.
Copyright: © 2025 ZHANG, Huang, Li, Yang, liang, Wei and Lu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: mei jia Lu, First Affiliated Hospital, Guangxi Medical University, Nanning, China
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