CASE REPORT article
Front. Oncol.
Sec. Surgical Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1550343
Doege-Potter syndrome: a giant solitary fibrous pleural tumor causing severe hypoglycemia
Provisionally accepted
- 1Fribourg Cantonal Hospital, Friborg, Switzerland
- 2Université de Fribourg, Fribourg, Fribourg, Switzerland
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Doege-Potter syndrome or non-islet-cell tumor hypoglycemia (NICTH) is a rare entity usually due to a solitary fibrous tumor of the pleura (pSFT). Diagnosis of NICTH is challenging because of its nonspecific clinical presentation and the rarity of pSFT.We present a case report of a 44-year-old woman diagnosed with NICTH to demonstrate the difficulty of establishing this diagnosis and the importance of preoperative preparation based on the characteristics of the lesion. We performed an embolization followed by an en bloc resection with diaphragmatic patch and lung wedge resection, and subsequently reconstructed the diaphragm with Prolene mesh through a left hemiclamshell incision. The postoperative course was favorable, particularly the resolution of hypoglycemia, which was concordant with the diagnosis. Pathological examination revealed a pSFT with clean margins and no features of malignancy detected by immunohistochemistry.This case report highlights the fact that diagnosing Doege-Potter syndrome is not always easy and often takes time after the patient’s initial presentation, the importance of preoperative planning, and the benefits of preoperative embolization of the arterial feeder.
Keywords: Non-Islet-Cell Tumor Hypoglycemia, NICTH, Solitary fibrous tumor of the pleura, PSFT, Doege-Potter syndrome
Received: 15 Jan 2025; Accepted: 12 May 2025.
Copyright: © 2025 De Vico, Tappero, Fontana, Lutz and Rouiller. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Benoît Rouiller, Fribourg Cantonal Hospital, Friborg, Switzerland
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