Clinicopathologic features and pathogenesis of hepatoid adenocarcinoma of the uterine cervix: a case report

Liu Yuanyuan^1,2Zhao Renfeng^2*

• ¹People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China
• ²Guangxi Academy of Sciences, Nanning, Guangxi Zhuang Region, China

Hepatoid adenocarcinoma (HAC) is a specific extrahepatic adenocarcinoma with hepatocellular differentiation, often associated with elevated serum alpha-fetoprotein (AFP).Hepatoid adenocarcinoma has been reported to occur in the stomach,ovaries, pancreas , uterus and other sites. Despite the poor prognosis and few effective treatment options, timely and accurate histopathological diagnosis is essential to optimize clinical management for long-term survival. Hepatoid adenocarcinoma of the uterine cervix is very rare and occurs mainly in postmenopausal women and the first symptom is irregular vaginal bleeding in all cases, with elevated serum AFP values. Hepatoid adenocarcinoma of the cervix is more prone to metastasis than ordinary cervical adenocarcinoma, and its prognosis is worse.The treatment plan still refers to the surgical treatment plan for cervical cancer, and radiotherapy or platinum-based combination chemotherapy is given after surgery.With the development of molecular pathology and next-generation sequencing technology, the pathogenesis of hepatoid adenocarcinoma is mainly related to hepatoid differentiation, gene mutation, and inflammatory stimulation. Only two cases have been reported in the literature, and one of the reasons for the lack of reports is the lack of knowledge of the clinical and pathological features of the disease, so improving clinical understanding of HAC is crucial for better identifying patients with hepatoid adenocarcinoma of the cervix.