REVIEW article
Front. Oncol.
Sec. Cancer Cell Signaling
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1552902
MicroRNAs in bone metastases: mechanisms and research progression
Provisionally accepted
- Ningxia Medical University, Yinchuan, China
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Bone metastasis, an exceedingly critical and often life -threatening complication in the course of diverse cancer progression, impacts nearly all tumor types, with an especially pronounced prevalence in breast, prostate, lung, liver, and thyroid malignancies. These metastatic lesions are typically localized in the spine, pelvis, shoulders, and distal femur, thereby exerting a substantial influence on patients' quality of life and prognosis. In numerous instances, the early detection of cancers frequently coincides with patients presenting symptoms induced by bone metastases, which strikingly highlights the severe and debilitating nature of this condition. MicroRNAs (miRNAs), a class of short non -coding RNAs, have emerged as pivotal regulators of gene expression. They are widely and comprehensively acknowledged for their indispensable role in cancer initiation, progression, invasion, and metastasis. Abundant evidence has underscored the involvement of specific miRNAs at various stages of bone metastasis, further emphasizing their vital contribution to the pathogenesis of metastatic bone disease. In this comprehensive review, we systematically collate and summarize the current state -of -the -art knowledge regarding the participation of miRNAs in bone metastasis within breast, prostate, lung, liver, and thyroid cancers. Moreover, we thoroughly explore the potential of miRNAs as therapeutic targets or advanced -generation therapeutic agents for bone metastasis. Concurrently, we also in -depth investigate their function as predictive biomarkers for earlier diagnosis and the development of optimized treatment strategies for cancer patients.
Keywords: Bone metastases1, MicroRNAs2, Breast cancer3, Prostate cancer4, lung cancer5, Liver cancer6 Bone metastasis, MicroRNAs, breast cancer
Received: 29 Dec 2024; Accepted: 16 Jul 2025.
Copyright: © 2025 He, Zhen and li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Wang Zhen, Ningxia Medical University, Yinchuan, China
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