ORIGINAL RESEARCH article
Front. Oncol.
Sec. Head and Neck Cancer
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1553626
This article is part of the Research TopicAdvancements in head and neck tumor treatment strategy driven by the perspective of precision oncologyView all 3 articles
Overexpression of NK4 gene in TU212 affects migratory activity in laryngeal squamous cell carcinoma
Provisionally accepted
- 1School of Clinical Medicine, Ningxia Medical University, Yinchuan, China
- 2Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu Province, China
- 3Lanzhou University, Lanzhou, Gansu Province, China
- 4Gansu Provincial Hospital, Lanzhou, Gansu Province, China
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Abnormal activation of the Hepatocyte Growth Factor (HGF) and c-Mesenchymal-epithelial transition factor (c-Met) signaling pathway is associated with tumor occurrence and development. Serum HGF concentrations are significantly higher in patients with advanced and poorly differentiated laryngeal squamous cell carcinoma than those with early and highly differentiated disease. NK4, a splice variant of HGF, can competitively bind to c-Met and acts as a specific antagonist of HGF. Although preliminary research has been conducted on the tumor-suppressing function of the NK4 gene, its specific mechanism of action in laryngeal cancer remains unclear.
Keywords: Apoptosis, Gene Expression, Laryngeal squamous cell carcinoma, NK4, RNA-Seq
Received: 31 Dec 2024; Accepted: 12 Jun 2025.
Copyright: © 2025 Huo, Zhang, Yang, Shao, Cong and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Shoukai Zhang, Gansu Provincial Hospital, Lanzhou, 730000, Gansu Province, China
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