CASE REPORT article
Front. Oncol.
Sec. Hematologic Malignancies
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1554956
Unveiling the Role of Genetic Abnormalities in Myelomatous Pleural Effusion: A Case of IgG Lambda-Type Multiple Myeloma
Provisionally accepted
- 1The First People’s Hospital of Shuangliu District, Chengdu, Chengdu, Sichuan Province, China
- 2Southern Medical University, Guangzhou, Guangdong, China
- 3Shanghai Changhai Hospital, Shanghai, China
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A 73-year-old male with a history of multiple myeloma presented with progressively worsening left shoulder pain that was unresponsive to conservative management. Following comprehensive diagnostic procedures, including imaging and genetic testing, he was diagnosed with IgG lambda-type multiple myeloma, complicated by the development of myelomatous pleural effusion (MPE). The patient's treatment regimen consisted of the PDD chemotherapy combination, including Bortezomib, Doxorubicin, and Dexamethasone, alongside adjunctive therapies aimed at controlling the pleural effusion. Post-treatment evaluation revealed resolution of the pleural effusion, with no detectable myeloma cells in the pleural fluid. This case illustrates the clinical utility of combining chemotherapy with supportive treatments for the effective management of MPE in multiple myeloma patients. The patient's positive response highlights the significance of tailoring therapeutic approaches to the individual, emphasizing the role of personalized care in improving clinical outcomes in similar complex cases of MPE.
Keywords: Multiple Myeloma, Myelomatous pleural effusion, Integrated treatment, diagnostic methods, Chemotherapy regimen
Received: 03 Jan 2025; Accepted: 29 May 2025.
Copyright: © 2025 Chen, Yan, Mo, Zhou and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yan Chen, Shanghai Changhai Hospital, Shanghai, China
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