REVIEW article
Front. Oncol.
Sec. Head and Neck Cancer
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1556662
This article is part of the Research TopicAdvances in the Treatment of Nasopharyngeal CancerView all 6 articles
The role of m6A methylation modification in nasopharyngeal carcinoma: a promising strategy
Provisionally accepted
- 1Nanjing Yimin Hospital, Nanjing, Liaoning Province, China
- 2Taizhou Central Hospital, Taizhou, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Nasopharyngeal carcinoma, one of the most prevalent malignant tumors globally, is an epithelial cancer that originates from the nasopharyngeal mucosa. RNA modification represents a post-transcriptional regulatory mechanism that is widely observed across various types of RNA, including mRNA, tRNA, rRNA, miRNA, and lncRNA. Among these, N6-methyladenine (m6A) is the most abundant methylated form present in mRNA. Numerous studies indicate that m6A modification is closely associated with human diseases, particularly cancer, and plays a crucial role in RNA transcription, splicing, stability, translation, and other processes. Notably, proteins related to m6A methylation modification are abnormally expressed in nasopharyngeal carcinoma tissue specimens, suggesting their potential as molecular targets for the diagnosis and treatment of this disease. In this review, we provide a comprehensive overview of the pivotal role of m6A in nasopharyngeal carcinoma, along with the latest advancements in diagnosis and molecular targeted therapy.
Keywords: M6A, nasopharyngeal carcinoma, biological function, Drug Resistance, Radiotherapy resistance
Received: 07 Jan 2025; Accepted: 19 May 2025.
Copyright: © 2025 Zeng, Song and Jin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Lijie Jin, Taizhou Central Hospital, Taizhou, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.