ORIGINAL RESEARCH article
Front. Oncol.
Sec. Surgical Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1557081
Analysis of risk factors for postoperative recurrence of stage IA lung adenocarcinoma
Provisionally accepted
- Tianjin Medical University General Hospital, Tianjin, China
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Objective: To explore the influencing recurrence in patients with stage IA lung adenocarcinoma following surgical resection. Method: A retrospective analysis was conducted on the clinical and pathological data of patients with stage IA lung adenocarcinoma who underwent surgical resection in the Department of Thoracic Surgery at Tianjin Medical University General Hospital from January 1, 2018, to December 31, 2021. The Fine-Gray model was utilized for multivariate analysis to identify factors influencing the cumulative incidence of lung cancer recurrence. The hazard ratio (HR) and its 95% confidence interval (CI) were calculated. Result: Among 475 patients, there were 30 cases of postoperative recurrence and metastasis. The results of the univariate analysis using the Gray test indicated that vascular invasion, STAS, solid and micropapillary patterns, pTNM classification, lymph node resection method, surgical method, organizational differentiation, CTR had a significant impact (P<0.05). The multivariate analysis revealed that pTNM classification，lymph node resection method，vascular invasion and the presence of solid or micropapillary patterns were significantly correlated. Conclusion: Tumor staging, the presence of solid or micropapillary components in pathology, vascular invasion, and the method of lymph node resection significantly influence postoperative disease-free survival (DFS) in patients with stage IA lung adenocarcinoma undergoing surgical resection.
Keywords: Lung Adenocarcinoma, Recurrence, Competing risk analysis, Vascular invasion, Postoperative recurrence
Received: 08 Jan 2025; Accepted: 23 Jul 2025.
Copyright: © 2025 Xu, Li, Tuerxun, Wang, Li, Li and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Peng Zhang, Tianjin Medical University General Hospital, Tianjin, China
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