CASE REPORT article
Front. Oncol.
Sec. Cancer Imaging and Image-directed Interventions
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1558053
This article is part of the Research TopicAdvances in Combined Modality Treatments for Prostate CancerView all 4 articles
Case Report: Primary Extraskeletal Osteosarcoma in Prostate
Provisionally accepted
Youli Xu
Xing Chen*- Chengdu Fifth People's Hospital, Chengdu, Sichuan Province, China
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Extraskeletal osteosarcoma (EOS) is an extremely uncommon malignant soft tissue sarcoma that carries a poor prognosis. However, EOS occurring in the prostate is especially rare. The purpose of this case report is to present the radiological features and immunohistochemistry results of the neoplasm in a 72-year-old man. In the case, contrast-enhanced CT and contrast-enhanced MRI clearly showed the primary lesion and the surrounding soft tissue invasion. In our case, massive calcification was seen within the tumor. Despite being regarded as a significant imaging symptom of EOS, calcification only happens in about half of cases. In our case, the positive immunohistochemistry results were included as follows: SATB2(+), SMA(+), CD99(+), CK(focal +), Ki-67(+, hot spots about 40%), P63(focal +), Vim(+). Extensive resection is the preferred treatment method for localized lesions; further adjuvant radiotherapy significantly decreased local recurrences, but chemotherapy did not decrease the risk of systemic recurrence.
Keywords: Prostate, Extraskeletal osteosarcoma, imaging, CT, MRI
Received: 09 Jan 2025; Accepted: 11 Jul 2025.
Copyright: © 2025 Xu and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xing Chen, Chengdu Fifth People's Hospital, Chengdu, Sichuan Province, China
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