CASE REPORT article
Front. Oncol.
Sec. Breast Cancer
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1560366
Breast Ductal Carcinoma In Situ With Microinvasion : A Case Tracked Over 13 Years
Provisionally accepted
- 1Department of Pathology, the affiliated Hospital of Southwest Mdical University., Luzhou, Sichuan Province, China
- 2Department of Pathology, Ya'an People’s Hospital, Yaan, Sichuan Province, China
- 3Department of Nuclear medicine,The Affiliated Hospital of Southwest Mdical University, Luzhou, China
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Background: Numerous studies have reported considerable heterogeneity within breast ductal carcinoma in situ with microinvasion (DCIS-MI) regarding clinical presentation, progression potential, and treatment strategies. Case Presentation: In this work, we report a case of rapidly progressing multiple metastases in a patient with DCIS-MI following conventional treatment. Subsequent FISH testing revealed HER2 gene overexpression. After receiving 10 cycles of trastuzumab-targeted therapy, the patient achieved a favorable prognosis and remains stable to date. Conclusion: This case suggests that even patients with microinvasive lesions who are HER2-positive may exhibit unexpected stability under targeted therapy, warranting close surveillance in such cases.
Keywords: breast cancer, Microinvasion, metastasis, therapy, Her2 gene
Received: 14 Jan 2025; Accepted: 15 Jul 2025.
Copyright: © 2025 Ruan, Zhou, Tang, Tao, Gao, Mou and Tang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Sibei Ruan, Department of Pathology, the affiliated Hospital of Southwest Mdical University., Luzhou, Sichuan Province, China
Mingxi Tang, Department of Pathology, the affiliated Hospital of Southwest Mdical University., Luzhou, Sichuan Province, China
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