CASE REPORT article
Front. Oncol.
Sec. Gastrointestinal Cancers: Colorectal Cancer
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1565838
This article is part of the Research TopicClinical Advances and Practice of Digestive System Cancer Progression and Metastasis Induced by Immune FactorsView all 5 articles
Bilateral Breast Metastases from Rectal Malignant Melanoma：Case Report and Literature Rewiew
Provisionally accepted
- 1Department of Oncology, People’s Hospital of Deyang City, Deyang, Sichuan Province, China
- 2Munich Technology Center, Technical University of Munich, Munich, Bavaria, Germany
- 3People’s Hospital of Deyang City, Deyang, Sichuan Province, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Rectal melanoma is an extremely rare and highly aggressive disease,and rectal melanoma metastasis to the breast is rare. This is a 48-year-old female who presented with rectal melanoma carcinoma Following the diagnosis of locally advanced rectal cancer (TxN3M0), she received chemotherapy, immunotherapy with radiotherapy, and metastases to the lung, bone and vulvar developed during the therapy. After one year of treatment, the patient developed bilateral breast metastases. Then breast site was identified using the gene expression assay which showed KIT mutation, indicating sensitivity to imatinib, so the patient had used imatinib for 2 months. But then the patient started to take Chinese medicine for personally reason. Sadly, the patient passed away 22 months after initial diagnosis due to rapidly progressive disease.This case showed a rare presentation of rectal melanoma metastasis to the breast. To our knowledge, this is also the first report of rectal melanoma metastasis to bilateral breasts.
Keywords: Rectal malignant melanoma, secondary malignant tumor of the breast, malignant melanoma, breast metastasis, case report
Received: 23 Jan 2025; Accepted: 31 Jul 2025.
Copyright: © 2025 Liu, Liu, Zhang, Liu, Cheng, Liao, Chen and Lu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Dingyu Lu, Department of Oncology, People’s Hospital of Deyang City, Deyang, Sichuan Province, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.