CASE REPORT article

Front. Oncol.

Sec. Neuro-Oncology and Neurosurgical Oncology

Volume 15 - 2025 | doi: 10.3389/fonc.2025.1565865

This article is part of the Research TopicEvolving Strategies in Radiation Therapy for Benign Intracranial Tumors: Current Techniques, Clinical Challenges, and Future ProspectsView all 4 articles

SOMATIC MALIGNANCY CLASSIFIED AS WILMS TUMOR ARISING WITHIN AN IMMATURE TERATOMA

Provisionally accepted
Emily Natalia MuñozEmily Natalia Muñoz1,2,3Cyrus WashingtonCyrus Washington1,2,3Pasquale BenedettoPasquale Benedetto1,2,4Ali SaadAli Saad1,2,5Oleksandr KryvenkoOleksandr Kryvenko1,2,5Dalissa TejeraDalissa Tejera1,6Macarena De La FuenteMacarena De La Fuente1,6Michael Edward IvanMichael Edward Ivan1,7,8Gregory AzzamGregory Azzam1,2,3*
  • 1University of Miami, Miami, United States
  • 2Jackson Memorial Hospital, Miami, United States
  • 3Sylvester Comprehensive Cancer Center and the Department of Radiation Oncology, Miami, United States
  • 4Sylvester Comprehensive Cancer Center and the Department of Hematology and Oncology, Miami, United States
  • 5Sylvester Comprehensive Cancer Center and the Department of Pathology, Miami, United States
  • 6Sylvester Comprehensive Cancer Center and the Department of Neurology, Miami, United States
  • 7Sylvester Comprehensive Cancer Center and the Department of Neurosurgery, Miami, United States
  • 8Jackson Memorial Hospital, Miami, Florida, United States

The final, formatted version of the article will be published soon.

Select one of your emails

You have multiple emails registered with Frontiers:

Notify me on publication

Please enter your email address:

If you already have an account, please login

You don't have a Frontiers account ? You can register here

Non-geminomatous germ cell tumors (NGGCTs) are aggressive malignancies characterized by their rapid metastatic potential. Teratomas are a subtype of NGGCTs and can present as mature (benign) or immature (malignant). Immature teratomas pose a higher metastatic risk than mature teratomas due to their embryonic-like tissue composition. Intracranial teratomas are rare in nature and can develop secondary malignancies such as Wilms tumors.We report the case of a 70-year-old male with a history of prostate cancer who presented with neurological symptoms and was diagnosed with a Wilms tumor arising within an immature teratoma. A heterogenous morphology, including squamous, cartilaginous, and neural differentiation, was revealed upon surgical resection. Despite interventions, the patient experienced rapid disease progression and eventually died in hospice care seven months after initial diagnosis. This case highlights the complexity of diagnosing and managing NGGCTs, particularly when secondary malignancies arise. Ultimately, it emphasizes the need for careful diagnosis and precise therapeutic strategies to manage these tumors.

Keywords: Wilms Tumor, Immature teratoma, non-geminomatous germ cell tumor, Somatic malignancy, Neuro-Oncology

Received: 23 Jan 2025; Accepted: 12 May 2025.

Copyright: © 2025 Muñoz, Washington, Benedetto, Saad, Kryvenko, Tejera, De La Fuente, Ivan and Azzam. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Gregory Azzam, University of Miami, Miami, United States

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Supplementary Material