ORIGINAL RESEARCH article
Front. Oncol.
Sec. Head and Neck Cancer
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1568697
Clinical Study on the Impact of Microwave Ablation Energy on the Treatment Efficacy of Benign Thyroid Nodules
Provisionally accepted
- 1Department of Ultrasound Medicine, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
- 2Department of Ultrasound Medicine, Harbin Medical University Cancer Hospital, Harbin, China
- 3Daqing People’s Hospital, Ultrasound Room, Daqing, China
- 4Department of Thyroid Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
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Objective: We aimed to establish a model to estimate the energy required for microwave ablation (MWA) to achieve the desired effect and analyze the factors influencing its therapeutic efficacy.Materials and Methods: We retrospectively analyzed 117 patients with benign thyroid nodules. A quadratic regression model was established to analyze the relationship between the technical parameters of MWA and volume reduction rate (VRR). Both univariate and multivariate logistic regression analyses were used to identify factors influencing the efficacy of MWA treatment. Results: The volume of nodules continued to decrease at 1, 3, 6, and 12 months after ablation, and the mean of VRR was 77.5 ± 15.9% at 12 months after ablation. Among these nodules, 72 (61.5%) had a VRR ≥ 75%, whereas 45 (38.5%) had a VRR < 75%. The energy volume ratio was significantly correlated with the VRR. When the VRR ≥ 75%, the energy volume ratio ranges 784-2,274 J/mL. Among all parameters, only the energy volume ratio and calcification were independent factors influencing the treatment efficacy for benign thyroid nodules (P < 0.05).Conclusions: The efficacy of the treatment was optimized when the energy volume ratio of the MWA fell within a certain range. The energy volume ratio and calcification are related to the efficacy of MWA treatment.
Keywords: Thyroid Nodule, Ablation Techniques, Microwaves, Energy Transfer, Ultrasonography
Received: 30 Jan 2025; Accepted: 23 Jun 2025.
Copyright: © 2025 Mei, Fu, Li, Ai, Sun, Tian, Leng and Jiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Shuangquan Jiang, Department of Ultrasound Medicine, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
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