ORIGINAL RESEARCH article
Front. Oncol.
Sec. Gynecological Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1568716
Global, Regional, and National Burden of Ovarian Cancer Attributable to High Body Mass Index, 1990-2021: Insights from the Global Burden of Disease Study 2021
Provisionally accepted
Yinghua Wang
Yuexin Yu*- Northern Theater Command General Hospital, Shenyang, Liaoning Province, China
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Objective: Building on established evidence linking excess body fatness to increased risk of ovarian cancer, this research aims to assess the global and regional disease burden of ovarian cancer attributable to high body mass index (BMI) from 1990 to 2021 using data from the Global Burden of Disease (GBD) study. Here, we specifically focus on quantifying trends in age-standardized mortality rates (ASMR) and age-standardized disability-adjusted life year rates (ASDR) to elucidate evolving epidemiological patterns and regional disparities.Methods: Comprehensive data were extracted from the GBD 2021 database to analyze trends in ASMR, ASDR, absolute deaths, and disability-adjusted life years (DALYs) attributable to high BMI-related ovarian cancer from 1990 to 2021, stratified by global, regional, and socio-demographic index (SDI) quintiles. The key methodological approaches included Joinpoint regression analysis to identify significant temporal changes in ASMR and ASDR trends and correlation analysis to determine associations between disease burden (ASMR/ASDR) and SDI. Additionally, future projections for ASMR and ASDR burdens from 2022 to 2050 were generated using a Bayesian Age-
Keywords: ovarian cancer, high body mass index, Global burden of disease, BapC, Obesity
Received: 02 Mar 2025; Accepted: 17 Oct 2025.
Copyright: © 2025 Wang and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yuexin Yu, w_y_h18240454130@163.com
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