ORIGINAL RESEARCH article
Front. Oncol.
Sec. Gastrointestinal Cancers: Gastric and Esophageal Cancers
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1570020
Diagnostic value of exosome non-coding RNAs as non-invasive biomarkers in gastric cancer: a meta-analysis
Provisionally accepted
Qiumiao Xu
Qinghong YanZhijiang DaiXiaoting ChenTongwei LiuChengjin PengGuoxin HuangXinyao Liu
Jingbin Wang*- Shenzhen Hospital of Guangzhou University of Chinese Medicine, Shenzhen, China
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Purpose: Gastric cancer, characterised by a significant mortality rate, is one of the most prevalent malignant neoplasms globally. Exosomal non-coding RNAs play a key role in gastric carcinogenesis, metastasis and treatment resistance by regulating gene expression, remodelling the tumour microenvironment and mediating drug resistance. In the identification of early gastric cancer, these exosomal non-coding RNA molecules possess significant potential to be developed into biomarkers that do not entail invasive procedures. Methods: Our study undertook a comprehensive and profound literature examination in core databases like PubMed, Web of Science, ScienceDirect, Embase, Scopus, and Medline, with the aim of precisely evaluating the potential effectiveness of exosomal miRNAs, lncRNAs, and circRNAs in the diagnosis of gastric cancer. Results: A sum of 52 studies were incorporated, comprising 164 studies. These studies identified a total of 59 miRNAs, 17 lncRNAs, and 16 circRNAs. For miRNAs, sensitivity was estimated at 0.72 (95% CI, 0.69 - 0.76) and specificity at 0.80 (95% CI, 0.77 - 0.83). For lncRNAs, the sensitivity was 0.86 (95% CI, 0.84 - 0.87) and the specificity was 0.82 (95% CI, 0.80 - 0.83). In the case of circRNAs, the sensitivity and specificity were 0.71 (95% CI, 0.63 - 0.78) and 0.88 (95% CI, 0.81 - 0.93) respectively. The AUC for miRNAs was calculated as 0.83. As for lncRNAs, its AUC was established to be 0.89. Regarding circRNAs, the determined AUC was 0.86. Conclusion: These results confirm the efficacy of exosomal ncRNAs as powerful biomarkers for the early diagnosis of gastric carcinomas, thereby laying a strong foundation for the advancement of novel diagnostic approaches.
Keywords: Exosomes, noncoding RNA, gastric cancer, biomarker, Meta-analysis
Received: 02 Feb 2025; Accepted: 28 May 2025.
Copyright: © 2025 Xu, Yan, Dai, Chen, Liu, Peng, Huang, Liu and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jingbin Wang, Shenzhen Hospital of Guangzhou University of Chinese Medicine, Shenzhen, China
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