CASE REPORT article
Front. Oncol.
Sec. Gynecological Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1570151
This article is part of the Research TopicAdvancements in Diagnostic and Management Strategies for Gynecological PathologiesView all 19 articles
Successful management for vulvar epithelioid sarcoma during pregnancy: A rare case report
Provisionally accepted
- 1The Third Affliated Hospital of Southern Medical University, Guangzhou, China
- 2The Seventh Affiliated Hospital of Southern Medical University, Foshan, China
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Vulvar epithelioid sarcoma (ES) in pregnancy is an exceedingly rare condition, and only three reports are available to date. Optimal management is not well established. Herein, we report a 35-year-old woman who presented with a tender mass on the left labia majora at 33 weeks and 4 days of gestation. The patient underwent radical local resection of the lesion in the left vulva and left inguinal lymphadenectomy at 36 weeks and 4 days of gestation. Simultaneously, preterm cesarian section was performed because of mature fetus indicated by ultrasonography. Pathology of the lesion demonstrated a 7×5×5 cm sized epithelioid sarcoma with the infiltration of surrounding adipose tissue and no necrosis, hemorrhage and venous invasion were identified. Six weeks after surgery, the patient underwent tumor resection due to recurrence. Then adjuvant radiotherapy was performed with a dose of 40 Gy/10 cycles, followed by 15 Gy/3 cycles with a 10×10 cm field. The patient survived with neither recurrence nor complications at a 12-months follow-up. This case highlights management of a rare disease in pregnancy, with radical local resection of the lesion and lymphadenectomy combined with cesarian section.
Keywords: Pregnancy, epithelioid sarcoma, Vulva, case report, cesarean
Received: 03 Feb 2025; Accepted: 25 Jun 2025.
Copyright: © 2025 Guo, Li, Liu and Xiong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Ribo Xiong, The Seventh Affiliated Hospital of Southern Medical University, Foshan, China
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