REVIEW article
Front. Oncol.
Sec. Head and Neck Cancer
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1570684
This article is part of the Research TopicMulti-Omics in Head and Neck Cancer: Unveiling Immunological Biomarkers for TherapyView all 6 articles
Progress of long-chain noncoding small nucleolar RNA host genes in thyroid cancer
Provisionally accepted
Tingyu Yang1,2
Yuanxu Xie2*- 1Bishan hospital of Chongqing Medical University, Chongqing, China
- 2Department of Oncology, Bishan Hospital of Chongqing Medical University, Chongqing, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Small nucleolar RNA host genes (SNHGs) are a class of long non-coding RNAs that are widely aberrantly expressed in thyroid cancer and regulate tumor progression through the "SNHG– miRNA–signaling pathway" network. SNHG7 promotes cell proliferation and metastasis via the PI3K/Akt pathway and correlates with radioactive iodine resistance; SNHG15 accelerates epithelial-mesenchymal transition via the Hippo-YAP1 pathway; SNHG12 drives malignant phenotypes by interacting with Wnt/β-catenin signaling; SNHG14 enhances tumor invasion through multiple miRNA axes. In contrast, SNHG3 and SNHG5 exhibit tumor-suppressive effects in some studies. Overall, SNHGs may serve as molecular biomarkers and hold potential therapeutic target value. However, existing evidence is largely based on in vitro and small-sample studies, requiring further validation in clinical cohorts and functional models.
Keywords: long noncoding RNA, nucleolar RNA host genes, Thyroid carcinoma, competitive endogenous RNA, Epithelial-Mesenchymal Transition
Received: 04 Feb 2025; Accepted: 16 Oct 2025.
Copyright: © 2025 Yang and Xie. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yuanxu Xie, 271823557@qq.com
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.