ORIGINAL RESEARCH article
Front. Oncol.
Sec. Neuro-Oncology and Neurosurgical Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1570941
This article is part of the Research TopicImpacts of 2021 WHO Classification on the Precise Diagnosis and Management of Gliomas, Volume IIView all 6 articles
Histopathological grading affects survival in patients with isocitrate dehydrogenasewildtype gliomas
Provisionally accepted
- Department of Neurosurgery, Beijing Luhe Hospital, Capital Medical University, Beijing, China
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The World Health Organization (WHO) Classification of Tumors of the Central Nervous System (2021) defines lower-grade (WHO grade II/III) isocitrate dehydrogenase (IDH) wildtype astrocytoma as glioblastoma, IDH-wildtype, WHO grade 4. However, this definition is conditional. Notably, the traditional histopathological grade is no longer used, and the independent prognostic factor of tumor grade in IDH wild-type gliomas remains unclear. In this study, we aimed to determine if histopathological grade is an independent prognostic factor.The clinical data and pathological information of 647 patients with IDH wild-type gliomas from the Chinese Glioma Genome Atlas (CGGA) database (2006-2019) were retrospectively analyzed. All patients were stratified according to histopathological grade and its prognostic significance in IDH wild-type gliomas. Univariate and Cox's multivariate analyses were used to determine the prognostic significance.The median follow-up time was 100.4 months, and the median survival time was 20.3 months. The histopathological grade was an important independent prognostic factor in the univariate and multivariate analyses, and a higher grade was associated with poor overall survival and progression-free survival. After further stratification by the extent of resection and postoperative adjuvant treatment, the histopathological grade remained a significant prognostic factor.In this study, histopathological grade affected survival in IDH-wild-type gliomas.This effect appears to be independent of the extent of resection and postoperative treatment. Thus, we suggest that clinical treatment of patients with IDH wild-type gliomas should continue to consider histopathological grade along with the molecular characteristics of the tumors.
Keywords: Histopathological grade, IDH-wildtype, Survival, Glioma, Chinese Glioma Genome Atlas
Received: 04 Feb 2025; Accepted: 29 Aug 2025.
Copyright: © 2025 Hou, Liu, Hou, Zhang and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Ziming Hou, Department of Neurosurgery, Beijing Luhe Hospital, Capital Medical University, Beijing, China
Hao Wang, Department of Neurosurgery, Beijing Luhe Hospital, Capital Medical University, Beijing, China
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