CASE REPORT article
Front. Oncol.
Sec. Gastrointestinal Cancers: Hepato Pancreatic Biliary Cancers
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1572348
This article is part of the Research TopicNovel Approaches in the Management of Hepatobiliary Pancreatic CancerView all 10 articles
A Rare Case of Hepatic Undifferentiated Pleomorphic Sarcoma: Diagnostic Dilemmas and Multidisciplinary Management Strategies
Provisionally accepted
- 1The First Clinical Medical College of China Three Gorges University, Yichang, Hubei Province, China
- 2Department of Hepatobiliary Surgery, Yichang Central People’s Hospital, Yichang, Hebei Province, China
- 3Department of Endocrinology, Yichang Central People’s Hospital, Yichang, China
- 4Qiqihar Medical University, Qiqihar, Heilongjiang Province, China
- 5Qiaokou District People's Hospital, WuHan, China
- 6Department of Pathology, Yichang Central People’s Hospital, Yichang, Hubei Province, China
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Undifferentiated pleomorphic sarcoma of the liver is an extremely rare mesenchymal malignancy, and there is limited literature on its clinical manifestations, diagnostic challenges, and therapeutic strategies. The case is unique due to its large tumour size, encapsulated feature, and lack of vascular invasion, offering new insights into tumour characteristics. This case was documented to contribute to the understanding of this aggressive tumour and highlight the role of multidisciplinary management in achieving favourable outcomes. A 57-year-old female presented with persistent upper abdominal pain for over two months. Laboratory tests showed anaemia, hypoalbuminemia and elevated AFP, and imaging revealed a large hepatic mass with necrosis. Initially, imaging misdiagnosed a large hepatic mass as hepatocellular carcinoma, but subsequent pathology and immunohistochemistry confirmed it was undifferentiated pleomorphic sarcoma. The patient successfully underwent left hepatic lobectomy with clear margins, and the resected tumour was a high-grade spindle cell tumour with significant necrosis. Postoperatively, the patient recovered well and was discharged in stable condition, with recommendations for further molecular diagnostics and oncological follow-up. In conclusion, early surgical intervention and multidisciplinary approaches are crucial for managing rare and aggressive hepatic tumours, such as undifferentiated pleomorphic sarcoma.
Keywords: undifferentiated pleomorphic sarcoma, Liver tumour, Rare malignancy, case report, multidisciplinary management
Received: 07 Feb 2025; Accepted: 07 Jul 2025.
Copyright: © 2025 Yang, Hou, Yi, Jiang, Tang, Hu and Xing. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Mingzheng Hu, The First Clinical Medical College of China Three Gorges University, Yichang, 443000, Hubei Province, China
Rongchun Xing, The First Clinical Medical College of China Three Gorges University, Yichang, 443000, Hubei Province, China
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