CASE REPORT article
Front. Oncol.
Sec. Gastrointestinal Cancers: Colorectal Cancer
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1576166
This article is part of the Research TopicInsights in Host Genetics and Microbial Interaction of Gastrointestinal DiseasesView all 4 articles
Ulcerative colitis combined with isolated superficially serrated adenoma: a case report
Provisionally accepted
- The First People's Hospital of Taicang, Taicang, China
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Introduction Superficially serrated adenoma (SuSA) is a recently identified type of serrated lesion characterized by a combination of adenomatous and serrated features. There are limited reports on SuSA currently, and its occurrence in conjunction with ulcerative colitis (UC) has not yet been documented.We present the case of a 38-year-old male with a 13-year history of ulcerative colitis (UC). During a routine follow-up colonoscopy, a superficial elevated lesion with a whitish surface was detected in the rectum, 10 cm from the anal verge. The lesion was removed en bloc via endoscopic submucosal dissection (ESD). Pathological analysis showed a combination of superficial serrated and vertically oriented adenomatoid glands. Immunohistochemistry indicated that the superficial epithelial cells exhibited serrated features and expressed CK20, while the middle and lower mucosal layers tested positive for Ki-67. Conclusion Although some studies have explored SuSA, many aspects of the disease remain unclear. This is the first reported case of UC combined with SuSA. Future reports are essential to enhance understanding of the potential link between UC and SuSA.
Keywords: superficial serrated adenoma, ulcerative colitis, Endoscopic resection, Pathological diagnosis, case report
Received: 13 Feb 2025; Accepted: 30 May 2025.
Copyright: © 2025 Gao, Nie, Zhang and Gong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Chen Gong, The First People's Hospital of Taicang, Taicang, China
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