REVIEW article
Front. Oncol.
Sec. Cancer Molecular Targets and Therapeutics
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1579423
This article is part of the Research TopicRenewed Insight into Cancer Mechanism and TherapyView all 26 articles
Unveiling the Impact of Lipid Metabolism on Triple-Negative Breast Cancer Growth and Treatment Options
Provisionally accepted
Xin-Xian Cai1,2
Zhezhong Zhang1Xiao-Xiao Yang1Wen-Rui Shen1,3Liu-Wei Yuan1,2Xi Ding1
Ying Yu1*
Wenyu Cai1*- 1The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine）, Hangzhou, Jiangsu Province, China
- 2School of Medical Technology and lnformation Engineering, Zhejiang Chinese Medical University, Hangzhou, Jiangsu Province, China
- 3First College of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China
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Triple-negative breast cancer (TNBC) is a subtype of breast cancer associated with poor prognosis and limited targeted treatment options. Lipid metabolism plays a pivotal role in the initiation, progression, and metastasis of TNBC by supporting cancer cell energy production, facilitating membrane biosynthesis, and regulating signal transduction. Dysregulation of lipid metabolism promotes tumor cell proliferation and contributes to processes such as epithelial-mesenchymal transition (EMT), angiogenesis, and immune evasion. Targeting lipid metabolism-such as inhibiting fatty acid synthase (FASN) and lipid metabolic byproducts-has emerged as a promising therapeutic strategy. The integration of multi-omics approaches and advanced imaging technologies can further elucidate the interactions between lipid metabolism and the tumor microenvironment, thereby supporting precision oncology. Future research should explore the role of lipid metabolism in distinct TNBC subtypes, optimize therapeutic strategies, and improve patient outcomes, particularly for those who are unresponsive to conventional treatments.
Keywords: Triple-negative breast cancer, Lipid Metabolism, Energy Metabolism, recurrence of metastases, Cell Death
Received: 19 Feb 2025; Accepted: 07 May 2025.
Copyright: © 2025 Cai, Zhang, Yang, Shen, Yuan, Ding, Yu and Cai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Ying Yu, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine）, Hangzhou, Jiangsu Province, China
Wenyu Cai, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine）, Hangzhou, Jiangsu Province, China
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