CASE REPORT article
Front. Oncol.
Sec. Gynecological Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1579795
Human Papillomavirus-Associated Anal Cancer, Vulvar Verrucous Cancer, and Cervical Cancer in a Post-Renal Transplant Patient-A Case Report
Provisionally accepted
- 1Department of Gynaecology and Obstetrics, The People's Hospital of Leshan, Leshan, China
- 2The People's Hospital of Leshan, Leshan, China
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Human papillomavirus (HPV) can cause tumors at specific anatomical sites in human body. Herein, we report the case of a 73-year-old female patient with a rare presentation of three distinct HPV-associated squamous cell carcinomas (anal, vulvar, and cervical), who had undergone kidney transplantation due to renal failure and was administered long-term cyclosporine, mycophenolate mofetil, and prednisone acetate for 20 years. Evidence of HPV16/59 infection was detected in Evidence of HPV16/59 infection was detected in formalin-fixed paraffin-embedded (FFPE) tissue samples obtained from the patient's vulvar tumor and anal tumor via PCR-based assays, as well as from exfoliated cells of the cervix. This case confirms the potential of HPV to drive carcinogenesis across multiple ano-genital sites within the same patient. Immunosuppression in transplant patients significantly increases the risk of human papillomavirus (HPV)-associated malignancies; however, the synchronous or metachronous development of triple anogenital cancers in a single individual is exceptionally uncommon. This case highlights the aggressive potential of HPV oncogenesis in immunocompromised hosts and underscores the need for rigorous cancer surveillance in this population.
Keywords: Human papillomavirus, Kidney Transplantation, vulvar verrucous carcinoma, Anal cancer, cervical cancer
Received: 19 Feb 2025; Accepted: 16 Jun 2025.
Copyright: © 2025 Feng, Shen, Yuan, Mao, Wang and Min. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Qing-Bo Shen, The People's Hospital of Leshan, Leshan, China
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