ORIGINAL RESEARCH article
Front. Oncol.
Sec. Genitourinary Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1580024
Relationship Between Immunohistochemical Markers and Clinical Pathological Variables in Clear Cell Renal Cell Carcinoma
Provisionally accepted
- 1Xingtai City People's Hospital, Xingtai, China
- 2Graduate School of Chengde Medical College, Chengde, China
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Objective: To explore the factors associated with the immunohistochemical results in clear cell renal cell carcinoma (ccRCC).This retrospective, single-center observational study included patients with pathologically confirmed ccRCC who underwent nephrectomy at Xingtai People's Hospital between January 2023 and October 2024. Logistic and linear regression was used to evaluate predictors of ccRCC features, with adjustments for demographic and clinical factors.Result ： Among the 50 patients (median age, 66 years; 64% male), high Vimentin expression was significantly associated with vascular invasion (adjusted OR, 2.90; 95% CI, 1.05-7.62; P = 0.031), lymph node metastasis (OR, 2.62; 95% CI, 1.03-8.12; P = 0.042), distant metastasis (OR, 3.10; 95% CI, 1.01-12.54; P = 0.048), and larger tumor size (P = 0.004). Ki-67 expression varied significantly by alcohol consumption (P = 0.024), perineural invasion (P = 0.038), and was positively correlated with serum creatinine (P = 0.017). CD10 expression was inversely correlated with bilirubin levels (P = 0.021) but not associated with invasive or metastatic features.Vimentin expression was strongly associated with markers of tumour invasiveness and may serve as a practical prognostic biomarker in ccRCC. Ki-67 may CC 删除[Zijing Yang]: 两端对齐, 行距: 1.5 倍行距 设置格式[Zijing Yang]: A total of 56 patients with newly diagnosed ccRCC admitted to the Department of Urology,
Keywords: Clear cell renal cell carcinoma, CD10, Vimentin, Ki-67, biomarker
Received: 20 Feb 2025; Accepted: 18 Jul 2025.
Copyright: © 2025 Liu, Wei and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Shubo Chen, Xingtai City People's Hospital, Xingtai, China
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