CASE REPORT article
Front. Oncol.
Sec. Radiation Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1580430
This article is part of the Research TopicRadiation Spatial Fractionation—A novel approach to integrate Physics, Biology, and Immunology for high therapeutic index radiotherapyView all articles
Metastatic Colon Adenocarcinoma to the Gingiva Treated with Spatial Fractionation Radiotherapy (SFRT): A Case ReportMetastatic Colon Adenocarcinoma to the Gingiva Treated with Spatial Fractionation Radiotherapy (SFRT): A Case Report
Provisionally accepted
- 1Graduate School, University of Electronic Science and Technology of China, Chengdu, China
- 2Department of Radiation Oncology, Sichuan Cancer Hospital, Chengdu, Sichuan Province, China
- 3Southwest Medical University, Luzhou, Sichuan, China
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Metastatic colon adenocarcinoma to the gingiva is exceedingly rare, accounting for 1-3% of maxillofacial malignancies and usually associated with advanced disease and poor prognosis.This case report describes a 68-year-old woman diagnosed with metastatic colon adenocarcinoma presenting with a metastatic lesion measuring 5 × 3 cm located in the left maxilla. The patient received hybrid spatial fractionation radiotherapy (SFRT) combining stereotactic body radiotherapy (SBRT) with conventional SFRT protocols. Post-radiotherapy, the lesion regressed significantly, bleeding ceased, and oral function improved. However, the patient passed away less than two months after the radiotherapy, due to the high systemic tumor burden and severe disease progression. This case highlights SFRT's efficacy in local symptom control for rare gingival metastases, despite systemic progression. This report underscores the need for optimized SFRT protocols and multidisciplinary approaches in managing metastatic colorectal cancer.
Keywords: Colonic Neoplasms, Neoplasm Metastasis, Radiotherapy, Spatially Fractionated Radiotion Therapy, Gingival metastasis
Received: 20 Feb 2025; Accepted: 02 Jul 2025.
Copyright: © 2025 Liu, Xu, Yao, Fang, Zhou and Lang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jinyi Lang, Department of Radiation Oncology, Sichuan Cancer Hospital, Chengdu, Sichuan Province, China
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