CASE REPORT article
Front. Oncol.
Sec. Pediatric Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1580494
Synchronous childhood T-lymphoblastic lymphoma and B-cell precursor acute lymphoblastic leukemia associated with constitutional MMR deficiency syndrome –a case report
Provisionally accepted
Joanna Bulsa1*
Agata Karolina Pastorczak2
Joanna Taha2
Wojciech Mlynarski2
Łukasz Sędek1
Tomasz Szczepanski1- 1Medical University of Silesia, Katowice, Poland
- 2Medical University of Lodz, Łódź, Łódź, Poland
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We present a four-year-old girl with synchronous T-cell lymphoblastic lymphoma (T-LBL) and B-cell precursor acute lymphoblastic leukemia (BCP-ALL).Development of two lymphoid malignancies arising from completely different cell lineages was confirmed by molecular tests. The cause of cancerogenesis in this patient was a genetic predisposition resulting from mismatch repair deficiency syndrome (CMMRD). Herein, we present the fatal course of the disorder, challenging treatment decisions and need for special approach to the patients with CMMRD-associated malignant proliferation.
Keywords: CMMRD, T-LBL, BCP-ALL, Genetic cancer predisposition, synchronous cancerogenesis
Received: 20 Feb 2025; Accepted: 28 Apr 2025.
Copyright: © 2025 Bulsa, Pastorczak, Taha, Mlynarski, Sędek and Szczepanski. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Joanna Bulsa, Medical University of Silesia, Katowice, Poland
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