SYSTEMATIC REVIEW article
Front. Oncol.
Sec. Gynecological Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1580940
This article is part of the Research TopicImmune Predictive and Prognostic Biomarkers in Immuno-Oncology: Refining the Immunological Landscape of CancerView all 25 articles
Prognostic role of fibrinogen-to-albumin ratio in patients with gynecological cancers: a meta-analysis
Provisionally accepted
Yaping Chen1
Jiliang Zhang2*- 1Maternal and Child Health Hospital of Changxing County, Huzhou, China
- 2Lishui City People's Hospital, Lishui, China
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Background: Fibrinogen-to-albumin ratio (FAR) has been widely studied for its prognostic value in gynecological cancers, but the results remain inconsistent. Therefore, this study aimed to evaluate the precise prognostic significance of FAR in gynecologic cancers.Methods: A comprehensive literature search was conducted in PubMed, Web of Science, Embase, the Cochrane Library, and China National Knowledge Infrastructure (CNKI) databases up to May 12, 2025. The prognostic value of FAR for overall survival (OS) and progression-free survival (PFS) in gynecologic cancers was examined using pooled hazard ratios (HRs) and corresponding 95% confidence intervals (CIs).Results: A total of 10 articles comprising 1,902 patients were included in this meta-analysis. Pooled results indicated that elevated FAR was significantly associated with poor OS (HR=2.75, 95% CI: 2.26–3.36, p<0.001) and shorter PFS (HR=1.60, 95% CI: 1.20–2.12, p=0.001) in patients with gynecologic cancers. Subgroup analyses confirmed that FAR predicted OS regardless of sample size, cancer type, FIGO stage, treatment modality, FAR threshold, threshold determination method, or type of survival analysis (p<0.05). Additionally, FAR remained a significant predictor of poor PFS across different cancer types.Conclusion: This meta-analysis showed that a high FAR is significantly associated with worse OS and PFS in patients with gynecologic cancers. FAR may serve as a promising prognostic biomarker in clinical practice.
Keywords: fibrinogen-to-albumin ratio, Meta-analysis, gynecological cancers, prognosis, Evidence-Based Medicine
Received: 21 Feb 2025; Accepted: 16 Jun 2025.
Copyright: © 2025 Chen and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jiliang Zhang, Lishui City People's Hospital, Lishui, China
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