CASE REPORT article
Front. Oncol.
Sec. Gastrointestinal Cancers: Hepato Pancreatic Biliary Cancers
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1581927
Thyroid Metastasis from Hepatocellular Carcinoma: A Rare Case Report and Literature Review
Provisionally accepted
- Hainan Branch of People's Liberation Army General Hospital, Sanya, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Thyroid metastasis is a relatively uncommon event in clinical practice, typically occurs in more prevalent primary tumors, including renal cell carcinoma and cancers of the gastrointestinal tract, lungs, and breast. The incidence of thyroid metastasis from primary hepatocellular carcinoma (HCC) is particularly infrequent. This case report outlines the clinical challenges and diagnostic pathway associated with a thyroid mass in a patient with HCC, highlighting the rarity and intricacy of such metastatic associations.A 51-year-old male with a long-standing history of hepatitis B-related liver cirrhosis presented with a rapidly enlarging painful left-sided thyroid mass 28 months after a diagnosis of HCC. FDG-PET/CT imaging revealed a 6 cm hypodense tumor in the left lobe of the thyroid and further fine needle aspiration cytology and biopsy (FNAB) confirmed it as a metastasis from HCC. The patient underwent transcatheter arterial chemotherapy embolization (TACE) as a first attempt to control the progress of the thyroid lesion. However, subsequent imaging showed a continued progression of the lesions in liver, along with other metastatic sites. Although multiple interventions, such as radiofrequency ablation (RFA) procedures was administered due to the progression of liver cancer and embolization therapies for the thyroid, the patient experienced significant deterioration, presenting with respiratory failure due to malignant pleural effusion.This unique case highlights the importance of promptly considering persistent or newly developed thyroid nodules as indicative of metastatic disease. The identification of thyroid metastases, especially in the context of extensive organ involvement, often correlates with a poor prognosis. Given the distinctive physiological properties of the thyroid gland, multidisciplinary management may offer clinical benefits for such patients with complex metastatic profiles. Combining locoregional therapies with immunotherapy, particularly dual immunotherapy, may offer significant prognostic advantages. Nevertheless, these hypotheses need to be verified through large-scale clinical trials.
Keywords: Hepatocellular Carcinoma, liver cancer, Thyroid metastasis, Transcatheter arterial chemotherapy embolization (TACE), case report
Received: 23 Feb 2025; Accepted: 22 May 2025.
Copyright: © 2025 Guan, Ye, Li and Ding. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Shasha Guan, Hainan Branch of People's Liberation Army General Hospital, Sanya, China
Panhua Li, Hainan Branch of People's Liberation Army General Hospital, Sanya, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.