CASE REPORT article
Front. Oncol.
Sec. Gastrointestinal Cancers: Gastric and Esophageal Cancers
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1582530
Concurrent esophageal squamous cell carcinoma with gastric mucosa-associated lymphoid tissue lymphoma: a case report
Provisionally accepted
- 1Zhejiang Provincial People's Hospital Bijie Hospital, Bijie, Guizhou Province, China
- 2Affiliated Hospital of Zunyi Medical University, Zunyi, China
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Background: Double primary malignant tumors are infrequently encountered, with esophageal squamous cell carcinoma (ESCC) co-occurring with malignancies in other organs representing a rare clinical entity. The concomitant presence of ESCC and lymphoma is even more uncommon, posing substantial diagnostic and therapeutic challenges. Case demonstration: A 76-year-old Han Chinese male presented with dizziness, dysphagia, and vomiting. Computed tomography suggested a potential esophageal neoplasm. Gastroscopy identified an ulcerated esophageal mass, accompanied by altered gastric body morphology and branching changes. Histopathological examination of biopsied esophageal and gastric mucosa confirmed ESCC concurrently with gastric mucosa-associated lymphoid tissue (MALT) lymphoma. The patient declined surgical intervention and succumbed 13 months after diagnosis. Conclusions: The simultaneous occurrence of ESCC and gastric MALT lymphoma remains exceedingly rare. In ESCC cases, the potential for coexisting malignancies in the pharynx, stomach, or other sites warrants consideration. This report documents the first known case of ESCC coexisting with gastric MALT lymphoma, contributing to current understanding of diagnosis and management strategies in lymphoma-associated ESCC cases.
Keywords: primary, Esophagus, Squamous cell carcinoma, Stomach, MALT lymphoma, combined
Received: 24 Feb 2025; Accepted: 08 Aug 2025.
Copyright: © 2025 Xu and Luo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Shuai Luo, Affiliated Hospital of Zunyi Medical University, Zunyi, China
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