CASE REPORT article
Front. Oncol.
Sec. Gastrointestinal Cancers: Hepato Pancreatic Biliary Cancers
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1584744
Mixed Adenoneuroendocrine Carcinoma(MANEC) of the Gallbladder ：A case report and literature review
Provisionally accepted
- 1Precision Pathological Diagnosis Center, Weifang People's Hospital, Weifang, China
- 2Department of Nuclear Medicine, Weifang People's Hospital, Weifang, China
- 3Department of Anesthesiology, Weifang People's Hospital, 151th, Weifang 261041, China, Weifang, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Adenocarcinoma (AC) and neuroendocrine carcinoma (NEC) in the gallbladder originate from glandular epithelium and neuroendocrine cells, respectively. AC and NEC are called mixed AC-NEC (MANEC) when they occur in the same tumor. The present study presents the case of a 57-year-old female individual who was diagnosed with gallbladder space. Gallbladder, S4b+5 resection of liver and hepatic pedicle lymph -node dissection were performed. Postoperative pathology confirmed MANEC in the gallbladder. No metastasis was found in the liver and pedicle lymph nodes. Given the rarity and high degree of malignancy of MANEC originating in the gallbladder, the previous literature was reviewed to enhance the understanding of the diagnosis and treatment of this tumor.
Keywords: Carcinoma, Gallbladder, Adenoneuroendocrine, Adenocarcinoma, neuroendocrine carcinoma
Received: 27 Feb 2025; Accepted: 11 Jul 2025.
Copyright: © 2025 Kong, Xu, Liu, Ma, Zou and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yunxuan Zou, Department of Anesthesiology, Weifang People's Hospital, 151th, Weifang 261041, China, Weifang, China
Xiu- Feng Li, Precision Pathological Diagnosis Center, Weifang People's Hospital, Weifang, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.