ORIGINAL RESEARCH article
Front. Oncol.
Sec. Molecular and Cellular Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1585433
This article is part of the Research TopicExploring the Tumor Microenvironment in Resectable Lung CancerView all articles
Prognostic significance of preoperative neutrophil-to-lymphocyte ratio in lung carcinoid patients after receiving curative surgery. A multicentre study
Provisionally accepted
Nicola Tamburini1*
Beatrice Aramini2
Ilaria Potenza1
Francesco Bagolini1
Danila Azzolina3Fares Shamshoum4
FEDERICO REA4
Franco Stella2
Giampiero Dolci1Enrica Pellizzer2
Pio Maniscalco1
Andrea Dell'Amore4- 1University Hospital of Ferrara, Ferrara, Italy
- 2Department of Medical and Surgical Sciences, Alma Mater Studiorum – Università di Bologna, Bologna, Emilia-Romagna, Italy
- 3University of Ferrara, Ferrara, Emilia-Romagna, Italy
- 4Thoracic Surgery Unit, Department of Cardiac, Thoracic and Vascular Sciences, School of Medicine and Surgery, University of Padua, Padua, Veneto, Italy
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BackgroundRecent evidence suggests that inflammation is relevant to carcinogenesis and tumor progression. Biomarkers of the inflammatory response are increasingly regarded as valuable prognostic indicators for enhancing predictive accuracy in non-small cell lung cancer (NSCLC). Nonetheless, the applicability of these measures in patients with pulmonary carcinoid remains uncertain.ObjectivesThe primary outcome of this study was to evaluate the prognostic impact on Overall Survival (OS) of the preoperative neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and serum C-reactive protein (CRP) in pulmonary carcinoid after complete surgical resection.MethodsWe retrospectively evaluated data from 267 patients who underwent surgery with curative intent for pulmonary carcinoid tumors between January 2010 and December 2020. Peripheral blood samples were collected preoperatively during routine preoperative tests. The univariable-unadjusted and the Inverse of Probability Weight (IPW) propensity score (PS) adjusted Cox regression models are reported to assess the association between inflammatory biomarkers and outcomes. ResultsThe median follow-up duration after surgical resection was four years. Elevated NLR was the only biomarker significantly associated with worse overall survival (OS). The significant association between NLR and OS is evidenced after adjusting for potential confounders using IPW.ConclusionsThis study demonstrated a significant association between the NLR in blood samples of carcinoid patients and their survival outcomes
Keywords: neutrophil-to-lymphocyte ratio (NLR), Pulmonary carcinoid, Survival & prognosis, non-small cell lung cancer (NSCLC), Serum C-reactive protein
Received: 28 Feb 2025; Accepted: 19 May 2025.
Copyright: © 2025 Tamburini, Aramini, Potenza, Bagolini, Azzolina, Shamshoum, REA, Stella, Dolci, Pellizzer, Maniscalco and Dell'Amore. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Nicola Tamburini, University Hospital of Ferrara, Ferrara, Italy
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