REVIEW article
Front. Oncol.
Sec. Neuro-Oncology and Neurosurgical Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1586515
Recent status and trends regarding oxidative stress in gliomas (2013 -2025): a systematic review and bibliometric analysis
Provisionally accepted
- 1Department of Pathology and Pathophysiology, Chengdu Medical College, Chengdu, 610500, China, Chengdu, China
- 2Department of clinical medicine, Chengdu Medical College, Chengdu, 610500, China, Chengdu, Sichuan Province, China
- 3Development and Regeneration Key Lab of Sichuan Province, Chengdu Medical College, Chengdu, Sichuan Province, China
- 4Graduate school, Chengdu Medical College, Chengdu, 610500, China, Chengdu, Sichuan Province, China
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BackgroundGlioma, a prevalent brain tumor originating from glial cells, exhibits rapid growth, high recurrence, and significant invasiveness. Standard treatments include surgery, radiotherapy, and chemotherapy, yet their effectiveness remains unsatisfactory. Recent studies implicate oxidative stress in promoting glioma cell proliferation and migration, as well as enhancing survival rates, suggesting antioxidant therapy as a potential tumor treatment strategy.ObjectiveThe aim of this review is to summarize the research hotspots on antioxidant treatment options for gliomas in the last twelve years and analyze the future trends through bibliometric analysis.MethodWe collected articles on oxidative stress in gliomas published between January 1, 2013 and April 5, 2025 using the Web of Science (WOS) database. We also visualized and analyzed annual publications, countries, and journals using VOSviewer, Citespace, and pajek. ResultThe search yielded a total of 1020 publications. Visual analyses show that the number of articles on this topic has increased annually over the last twelve years. Most of the studies came from China, followed by the United States. The three most cited journals were International Journal of Molecular Sciences, Cancer and Frontiers in Oncology. The author who published the most articles on this topic was Wang HD.ConclusionThrough a systematic analysis, we found that current research hotspots mainly focus on the dose of reactive oxygen species (ROS) and tumor proliferation, inflammatory response, apoptosis, etc. in relation to oxidative stress. In addition, we analyzed the direction of future research: a possible focus on the treatment of gliomas via 'tumor microenvironment', 'blood-brain barrier', 'anti-inflammatory' and ' ferroptosis induction ' routes.
Keywords: Oxidative Stress, gliomas, Bibliometrics, Citespace, VOSviewer, visualization
Received: 03 Mar 2025; Accepted: 22 Apr 2025.
Copyright: © 2025 Zeng, Lu, Wang, He, Zhang, Cao and Cheng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Lushun Zhang, Department of Pathology and Pathophysiology, Chengdu Medical College, Chengdu, 610500, China, Chengdu, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.