ORIGINAL RESEARCH article
Front. Oncol.
Sec. Breast Cancer
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1587243
Multidimensional Evaluation of 3.0T HR-MRI, Ultrasound Imaging, and GATA3 Protein Expression in Breast Cancer, and Their Prognostic Analysis
Provisionally accepted
- 1The Second Affiliated Hospital, Department of Ultrrasound Mddicine, Hengyang Medical School, University of South China, Hengyang, China
- 2The Second Affiliated Hospital, Department of Emergency, Hengyang Medical School, University of South China, Hengyang, China
- 3The Affiliated Nanhua Hospital, Department of Emergency, Hengyang Medical School, University of South China, Hengyang, China
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Objective: To evaluate the diagnostic value of 3.0T high-resolution magnetic resonance imaging (3.0T HR-MRI), ultrasound imaging, and GATA3 protein expression in breast cancer (BC) and their prognostic implications.A retrospective analysis of 143 BC patients was conducted. All patients underwent preoperative 3.0T HR-MRI and ultrasound examinations. Diffusion tensor imaging (DTI) parameters, including mean diffusivity (MD), fractional anisotropy (FA), radial diffusivity (Dr), and axial diffusivity (Da), were assessed. Ultrasound features such as tumor morphology, vascularity, and posterior acoustic characteristics were analyzed. Immunohistochemistry was performed to detect GATA3 expression, and correlations with imaging parameters and prognosis were evaluated.Results: GATA3 expression was significantly associated with BC pathological subtypes ( 2 x = 26.59, P < 0.0001). Compared with the GATA3-negative group, GATA3-positive tumors exhibited lower FA but higher MD, Dr, and Da values (P < 0.05), suggesting more preserved tissue structure. Ultrasound analysis showed that GATA3-positive tumors had less vascularity, posterior attenuation, and irregular margins (P < 0.05). Poor prognosis was associated with higher FA and lower MD, Dr, and Da values (P < 0.0001), as well as more aggressive ultrasound features. ROC analysis demonstrated superior prognostic performance when combining GATA3 expression, MRI, and ultrasound parameters (AUC = 0.9695, sensitivity = 83.54%, specificity = 96.88%).3.0T HR-MRI and ultrasound provide complementary insights into BC characteristics. GATA3 expression is associated with better prognosis, and their combined analysis enhances diagnostic accuracy and prognostic evaluation.
Keywords: high-resolution magnetic resonance imaging, ultrasound, GATA3, breast cancer, Diffusion Tensor Imaging
Received: 04 Mar 2025; Accepted: 09 Jul 2025.
Copyright: © 2025 Bai, Xie, Mo, Luo and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Man Chen, The Second Affiliated Hospital, Department of Ultrrasound Mddicine, Hengyang Medical School, University of South China, Hengyang, China
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