CASE REPORT article
Front. Oncol.
Sec. Gynecological Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1587411
This article is part of the Research TopicAdvances in New Biomarkers for the Diagnosis and Therapy of Gynaecological TumoursView all 6 articles
Early Detection of Left Fallopian Tube Carcinosarcoma by Transvaginal Sonography: A Case Report and Review of Diagnostic Challenges
Provisionally accepted
- 1Medical Ultrasound, Taihe Hospital, Hubei University of Medicine, Shiyan, China
- 2Pathology, Taihe Hospital, Hubei University of Medicine, Shiyan, China
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Fallopian tube carcinosarcoma (FTCS) is an extremely rare and aggressive malignancy, its nonspecific clinical presentation and anatomical location make preoperative diagnosis challenging, often lead to delayed treatment and poor outcomes. Here, we present a case of early-stage FTCS in a 57-year-old postmenopausal woman who presented with vaginal bleeding. Transvaginal sonography (TVS) played a pivotal role in identifying a characteristic sausage-shaped adnexal mass, which was missed on enhanced computed tomography (ECT).The patient underwent comprehensive surgical staging, including total hysterectomy and bilateral adnexectomy, with pathology confirming FTCS, FIGO stage IA.Immunohistochemical analysis revealed a biphasic tumor with strong P53 positivity and a high Ki-67 index (80%), indicative of its aggressive nature. Despite declining adjuvant therapy beyond two cycles of chemotherapy, the patient remained recurrence-free at 24 months postoperatively. This case highlights the critical role of TVS in the early detection of FTCS and underscores the importance of timely surgical intervention in improving outcomes.We also discuss the diagnostic challenges, pathological features, and therapeutic considerations of FTCS, emphasizing the need for further research to optimize diagnostic and treatment strategies for this rare malignancy.
Keywords: primary fallopian tube carcinosarcoma, Malignant mixed Müllerian tumors, Transvaginal sonography, case report, Imaging diagnosis
Received: 04 Mar 2025; Accepted: 06 Aug 2025.
Copyright: © 2025 Chang, Zhang, Wang, Song and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Wenjun Zhang, Medical Ultrasound, Taihe Hospital, Hubei University of Medicine, Shiyan, China
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