ORIGINAL RESEARCH article
Front. Oncol.
Sec. Cancer Imaging and Image-directed Interventions
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1587714
This article is part of the Research TopicAdvances in Oncological Imaging TechniquesView all 14 articles
A Retrospective Analysis of Multiparametric Ultrasound Features in Chromophobe Renal Cell Carcinoma
Provisionally accepted
- 1Fujian Medical University, Fuzhou, China
- 2Fujian Provincial Hospital, Fuzhou, Fujian Province, China
- 3Fujian Maternity and Child Health Hospital, Fuzhou, Fujian Province, China
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Objective: To analyze the echo intensity values, conventional ultrasound features, and contrast-enhanced ultrasound (CEUS) characteristics of chromophobe renal cell carcinoma (chRCC), aiming to provide a valuable reference for the non-invasive clinical diagnosis of chRCC. Methods: This retrospective study included 52 patients with pathologically proven chRCC at Fujian Provincial Hospital between June 2010 and January 2024, all of whom underwent ultrasound examinations prior to treatment. Two ultrasound specialists assessed the imaging features of each tumor, and 3D Slicer software was utilized to measure the echo intensity values of the renal cortex, renal mass, and renal sinus from the same ultrasound scan plane.Results: 51.9% of the patients included in this study were male, with an average age of 52.8 years. Quantitative echo intensity measurements showed that only 23.1% (12/52) of the tumors had lower echo intensity compared to the renal cortex, whereas 75.0% (39/52) had values between those of the renal cortex and renal sinus. The median tumor-to-renal cortex echo intensity ratio was 1.18, with the first and third quartiles (Q1, Q3) being 1.01 and 1.78, respectively. Conventional ultrasound analysis revealed that 80.8% (42/52) of the tumors exhibited a regular shape, while 78.9% (41/52) were completely or predominantly solid. In CEUS, 48.4% (15/31) of the tumors exhibited slow wash-in, while 77.4% (24/31) showed fast wash-out. Furthermore, 71.0% (22/31) demonstrated homogeneous peak enhancement, and 61.3% (19/31) displayed perilesional rim-like enhancement (PRE).The combination of conventional ultrasound features and CEUS characteristics of chRCC with quantitative echo intensity analysis enhances diagnostic objectivity and holds promise for non-invasive preoperative differentiation of RCC subtypes.
Keywords: Chromophobe renal cell carcinoma, 3D Slicer, Conventional Ultrasound, contrast-enhanced ultrasound, Echo intensity values
Received: 04 Mar 2025; Accepted: 21 Jul 2025.
Copyright: © 2025 Lin, Lin, Tang, Hu and Songsong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Wu Songsong, Fujian Medical University, Fuzhou, China
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