CASE REPORT article
Front. Oncol.
Sec. Head and Neck Cancer
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1588295
The Role of Ultrasound in Diagnosing 2mm Medullary Thyroid Carcinoma with Cervical Lymph Node Metastasis: A Case Report
Provisionally accepted
- 1Department of Ultrasound Medicine, Baoji Central Hospital, Baoji, China
- 2Department of Pathology, Baoji Central Hospital, Baoji, China
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Abstract Background Medullary thyroid carcinoma (MTC) is a rare, aggressive thyroid cancer, comprising 5%-10% of cases, often leading to cervical lymph node metastasis. Case presentation We report a 49-year-old woman with a 2 mm micro-nodule in the left thyroid lobe and two suspicious lymph nodes in the neck. Ultrasound-guided fine needle aspiration indicated MTC, confirmed by immunohistochemical analysis. Following total thyroidectomy and left cervical lymphadenectomy, two of 26 lymph nodes showed metastasis. The cancer was 2 mm, with no capsular invasion, and positive markers for MTC were noted. This case emphasizes the importance of early MTC detection in micro-nodules and thorough lymph node evaluation. Conclusion Even a 2 mm MTC has the potential to metastasize lateral cervical lymph nodes. This emphasizes the necessity of meticulous ultrasound evaluation by experienced clinicians to detect abnormal lymph nodes and inform clinical management. Interventional ultrasound plays a crucial role in both diagnosing MTC micro-nodules and identifying associated lymph node metastases.
Keywords: Thyroid medullary carcinoma, lymph node metastasis, High-frequency ultrasound, Fine needle aspiration, cytology
Received: 05 Mar 2025; Accepted: 05 Sep 2025.
Copyright: © 2025 Wan, Sun, Gan and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jianxue Liu, Department of Ultrasound Medicine, Baoji Central Hospital, Baoji, China
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