PERSPECTIVE article
Front. Oncol.
Sec. Pediatric Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1588403
This article is part of the Research TopicCritical Complications In Pediatric Oncology and Hematopoietic Cell Transplant - Volume IIIView all 7 articles
New perspectives on extracorporeal life support: expert teams and precise selection of candidates are transforming pediatric cancer and hematopoietic cell transplantation care
Provisionally accepted
Caitlin Hurley1
Matteo Di Nardo2
Matthew Rees1
Diego Raul Hijano1
Ahmed S Said3
Akshay Sharma1
LAMA ELBAHLAWAN1
Melissa R Hines1
Jennifer Ann McArthur1
Hitesh Singh Sandhu4
Saad Ghafoor1*- 1St. Jude Children's Research Hospital, Memphis, United States
- 2Bambino Gesù Children's Hospital (IRCCS), Rome, Lazio, Italy
- 3Washington University in St. Louis, St. Louis, Missouri, United States
- 4University of Tennessee Health Science Center (UTHSC), Memphis, Tennessee, United States
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Extra Corporeal Life Support (ECLS) for pediatric oncology and stem cell transplant patients over the past two decades has made progress. Substantial improvements in ECLS, Continuous Renal Replacement Therapy (CRRT), and mechanical ventilation techniques, along with enhanced anticoagulation management and infection control, have contributed to better patient outcomes. Additionally, advancements in HLA matching, donor selection, and the management of chemotherapy and transplant complications have further improved survival rates. The authors propose establishing an expert team and a standardized process to evaluate ECLS candidacy, addressing past controversies and optimizing outcomes for this vulnerable population. The criteria for candidacy have evolved significantly, necessitating expert evaluation.
Keywords: Extracorporeal life support (ECLS), Extracorporeal membrane oxygenation (ECMO), pediatric oncology, pediatric hematopoietic cell transplant, pediatric critical care
Received: 05 Mar 2025; Accepted: 26 May 2025.
Copyright: © 2025 Hurley, Di Nardo, Rees, Hijano, Said, Sharma, ELBAHLAWAN, Hines, McArthur, Sandhu and Ghafoor. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Saad Ghafoor, St. Jude Children's Research Hospital, Memphis, United States
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.