ORIGINAL RESEARCH article
Front. Oncol.
Sec. Thoracic Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1589325
This article is part of the Research TopicRecent Advances in Radiation Oncology for the Management of Thoracic MalignanciesView all 8 articles
Dose and local efficacy analysis of iodine-125 seed implantation therapy for lung tumors
Provisionally accepted
- 1Department of Oncology, Hebei General Hospital, Shijiazhuang, Hebei Province, China
- 2Department of Radiotherapy, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China
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Abstract Objective: To explore the dose and local efficacy of iodine-125 seed implantation therapy for lung tumors. Methods: The clinical data of 85 patients with lung tumors who underwent iodine-125 seed implantation therapy were retrospectively analyzed. The impact of prescription dose D90 (minimum peripheral dose received by the 90% target volume) on the local treatment effect six months after seed implantation was analyzed, and the critical value for predicting efficacy was determined. Factors affecting the local complete response (CR) rate six months after surgery were also analyzed.The local control rate six months after treatment was 89.41% (76/85), and the objective response rate (ORR) was 70.59% (60/85), with a CR rate of 31.76% (27/85). Patients with a post-procedure D90 > 140 Gy had a significantly higher local CR rate. Multivariate analysis revealed that post-procedure D90 and tumor size were independent prognostic factors for achieving CR six months after lung tumor seed implantation. Conclusion: Iodine-125 seed implantation therapy is effective for lung tumors. Tumor size (P = 0.0003) and post-procedure D90 (P = 0.0005) were found to be independent prognostic factors for achieving post-procedure CR after lung tumor seed implantation.
Keywords: D90, iodine-125 seed, lung tumor, prognostic factors, tumor size
Received: 07 Mar 2025; Accepted: 06 Jun 2025.
Copyright: © 2025 Cao, Chang, Wang, Liu, Xu, Wang and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Hongtao Zhang, Department of Oncology, Hebei General Hospital, Shijiazhuang, 050051, Hebei Province, China
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