CASE REPORT article
Front. Oncol.
Sec. Surgical Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1590061
Iodine-125 Brachytherapy for Orbital-Invasive Low-Grade Myxofibrosarcoma of the Maxillary Sinus: A Case Report Challenging Conventional Therapeutic Paradigms
Provisionally accepted
Qiyu Sun1
Shuai Li2Quanli Qiu1Yanbo Hu1Rui Huang2Yan Chen2Zhenzhen Cui2
Jiaxin Yang2Xiaowen Ma2*
Min Li2*- 1Jinzhou Medical University, Jinzhou, Liaoning Province, China
- 2960th Hospital of the PLA, Jinan, China
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Low-grade myxofibrosarcoma (LGMFS) is a rare subtype of soft tissue sarcoma, with an estimated incidence of approximately 0.18 cases per million population, accounting for about 0.6% of all soft tissue sarcomas. It is characterized by a high local recurrence rate and malignant potential. Orbital involvement secondary to maxillary sinus LGMFS represents an exceptionally rare occurrence. The management of such cases is complicated by anatomical complexity (e.g., proximity to optic nerve, lacrimal apparatus, and orbital vasculature) and limitations of conventional therapies, including radical resection combined with chemoradiation. In this anatomically complex case of recurrent Low-Grade Myxofibrosarcoma, iodine-125 brachytherapy achieved durable local control (12-month progression-free survival), demonstrating superior precision targeting and reduced systemic toxicity compared to conventional therapies. No acute radiation toxicity was observed, while facial swelling and eye pain were relieved with concurrent improvement in visual function.
Keywords: Low-grade myxofibrosarcoma, Iodine-125 brachytherapy, Orbital-Invasive, case report, CT-guided
Received: 11 Mar 2025; Accepted: 29 Sep 2025.
Copyright: © 2025 Sun, Li, Qiu, Hu, Huang, Chen, Cui, Yang, Ma and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xiaowen Ma, yuetianzhixiu@sina.com
Min Li, liminyingxiang@163.com
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