CASE REPORT article
Front. Oncol.
Sec. Gastrointestinal Cancers: Gastric and Esophageal Cancers
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1590544
Case Report and Literature Analysis of Ectopic Gastric Glands Combined with Intestinal-Type Gastric Cancer in an HP-Negative Background
Provisionally accepted
Shiyu Peng
shuxin tian*- Department of Gastroenterology, the First Affiliated Hospital of Medical College, Shihezi University, Shihezi, Xinjiang Uyghur Region, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
We report a rare case of intestinal-type gastric cancer combined with submucosal ectopic gastric glands in a patient without Helicobacter pylori (HP) infection. A 55-year-old female presented for a routine health check-up. Gastroscopy revealed a lesion approximately 2.0 cm in size, classified as type O-IIa+IIc, located on the posterior wall of the upper gastric body. Endoscopic biopsy indicated high-grade intraepithelial neoplasia, which promoted endoscopic submucosal dissection (ESD). Pathological examination confirmed mucosal adenocarcinoma with submucosal ectopic gastric glands. Given the association of such lesions with gastric cancer, careful diagnosis and treatment are essential. The patient remained disease-free without recurrence during a 2-year follow-up period.
Keywords: Submucosal ectopic gastric glands, Early Gastric Cancer, case report, A 55-year-old female, Pathological examination
Received: 09 Mar 2025; Accepted: 19 May 2025.
Copyright: © 2025 Peng and tian. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: shuxin tian, Department of Gastroenterology, the First Affiliated Hospital of Medical College, Shihezi University, Shihezi, Xinjiang Uyghur Region, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.