ORIGINAL RESEARCH article
Front. Oncol.
Sec. Surgical Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1591306
Surgical treatment of giant phyllodes tumors of the breast: a series of rare cases
Provisionally accepted
- Peking Union Medical College Hospital (CAMS), Beijing, China
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Background: Phyllodes tumors (PTs) are rare interstitial tumors that account for <1% of all breast tumors. The best surgical option for PTs is controversial, particularly in patients with giant PTs. Methods: This retrospective single-center study selected patients with giant borderline/malignant PT (>10 cm) treated in our center between January 2017 and July 2022. We conducted a detailed analysis and identified rare cases. Survival analysis was performed using the Kaplan–Meier method. Results: This study included 24 patients with PTs >10 cm, including 15 borderline and nine malignant PTs. Among these patients, 12 underwent extended lumpectomy and 12 underwent mastectomy at initial diagnosis. All patients were followed up for a median of 49.8 months. Local recurrence occurred in 50% of the patients who underwent lumpectomy, whereas none of the patients who underwent mastectomy and achieved R0 resection had recurrence. Several special cases are described in detail separately. Conclusion: Mastectomy may reduce local recurrence rates in patients with giant borderline/malignant PTs of the breast. Complete tumor resection and clean margins are the most important factors in controlling local recurrence.
Keywords: Breast, Phyllodes Tumor, Surgery, Giant tumor, Rare cases
Received: 11 Mar 2025; Accepted: 30 Sep 2025.
Copyright: © 2025 Chen, Xu, Huang, Lin and Sun. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yan Lin, linyan@pumch.cn
Qiang Sun, 277630399@qq.com
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