CASE REPORT article
Front. Oncol.
Sec. Surgical Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1591905
Subhepatic Appendicitis Complicated by Hepatic Abscess as the Initial Presentation of Primary Diffuse Large B-Cell Lymphoma of the Appendix: First Reported Case
Provisionally accepted
- China Aerospace Science and Industry Corporation, Haidian, China
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Subhepatic appendicitis complicated by hepatic abscess is an uncommon clinical condition due to anatomical variations in the appendix's position. Here, we report an unusual case of a 56-year-old male who initially presented with right abdominal pain and fever, misdiagnosed as bilateral kidney stones and urinary tract infection.Subsequent abdominal CT(Computed Tomography) scans revealed subhepatic appendicitis with a hepatic abscess located in segment VI of the liver. The patient underwent successful laparoscopic appendectomy and hepatic abscess drainage. Unexpectedly, histopathological examination of the appendix demonstrated diffuse large B-cell lymphoma (DLBCL), a rare form of primary appendiceal non-Hodgkin lymphoma. Immunohistochemistry confirmed the diagnosis, with tumor cells positive for CD20, CD79a, Bcl-6, and c-Myc, and a high Ki-67 proliferative index (>90%). This case highlights the diagnostic challenges associated with atypically positioned appendicitis and underscores the importance of pathological evaluation in detecting rare underlying malignancies.
Keywords: Subhepatic appendicitis, Liver Abscess, Diffuse large B-cell lymphoma, non-Hodgkin lymphoma, Appendectomy, case report
Received: 20 Mar 2025; Accepted: 28 May 2025.
Copyright: © 2025 Chen, Yu, Chan, Li, Fan, Shang and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Huili Zhang, China Aerospace Science and Industry Corporation, Haidian, China
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