ORIGINAL RESEARCH article
Front. Oncol.
Sec. Genitourinary Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1592406
This article is part of the Research TopicUrothelial Neoplasms: An Integrated Approach to Prevention, Diagnostics, and Personalized TherapyView all 5 articles
Clinical efficacy of laparoscopic radical cystectomy with intracorporeal urinary diversion and an analysis of factors influencing complications. Author Information
Provisionally accepted
- Department of Urology, Renmin Hospital, Hubei University of Medicine, Shiyan, China
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Purpose: To explore the feasibility of combined laparoscopic radical cystectomy (LRC) and intracorporeal urinary diversion (ICUD) in the treatment of bladder cancer, as well as the influencing factors related to complications.: A retrospective study was conducted on 116 bladder cancer patients who underwent LRC at our facility between January 2019 and December 2023. Based on the different urinary diversion methods, 78 patients received extracorporeal urinary diversion (ECUD), while 38 patients underwent intracorporeal urinary diversion (ICUD). The two groups were compared in terms of clinicopathologic data, perioperative outcomes, postoperative tumor control, complication rates, and their influencing factors.Results: No statistically significant differences were observed between the two groups in terms of median total operative time, hospital stay, perioperative transfusion rate, and short-term oncological outcomes. Compared to the ECUD group, the ICUD group experienced less intraoperative blood loss (200 ml vs. 350 ml) and an earlier start to postoperative liquid diet intake (4 days vs. 5 days) (p < 0.05). A total of 24 cases of ≥ III grade complications occurred within 90 days postoperatively, with 20 cases in the ECUD group and 4 in the ICUD group. There was no significant difference in the incidence of ≥III grade complications between the two groups (p > 0.05). Sepsis was the most common major complication. Logistic regression analysis identified smoking history, diabetes, and intraoperative blood loss as independent risk factors for ≥III complications.Conclusions: ICUD is a secure and effective method with advantages such as improved postoperative bowel recovery, reduced intraoperative blood loss, and fewer overall postoperative complications. Furthermore, major complications are influenced by multiple risk factors and should be carefully considered during preoperative and postoperative management.
Keywords: Bladder cancer, Laparoscopy, Urinary Diversion, complications, Risk factors
Received: 12 Mar 2025; Accepted: 19 May 2025.
Copyright: © 2025 Fang, Ji, Shi, Zhou, Xu, Luo and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yunfei Li, Department of Urology, Renmin Hospital, Hubei University of Medicine, Shiyan, China
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